United States: Darier disease (DD) is a skin condition that you perhaps hear called keratosis follicularis or Darier-White disease. It is a genetic illness, which means it can be passed down from parents to children. Usually, this disease starts showing up in teenagers and can become more noticeable as girls grow up.
However, there isn’t much research about how Darier disease affects the skin and unborn babies, especially when it affects areas like the groin and vulva. Understanding more about this condition is important for helping those who have it!
As reported by Cureus, DD is an autosomal dominant genodermatosis with referred penetrance and highly variable geographic prevalence and its occurrence is estimated as 1,30,000 . This is an illness that has parity between the genders; it is result from mutation of the ATP2A2 gene. Changes in ATP2A2 gene, responsible for the calcium (Ca²+) ATPase pumps – SERCA2 in endoplasmic reticulum.
Stress, dizziness, high temperatures, UV rays and lithium carbonate are aggravating extension attributes. The most common secondary infections that flares may present are bacterial infection (Staphylococcus aureus), viral (herpes simplex virus and human papillomavirus) and itching and malodor.
Prior studies have established antecedent and further improvements of the disease throughout pregnancy with bacterial as well as viral infections . Although, there are reports of flare that occur at certain periods such as menstruation, and pregnancy, it is believed that these are not very widespread because generally, high estrogen environment puts less activity in Darier .
Also, there exists a lack of surrounding literature regarding the possibility of impacts of DD during the pregnancy period and, in particular, when it occurs in the area of the abdomen.
It remains the case that this is one of the few cases of DD complicating pregnancy reported in the literature. On an average, pregnancy and DD has been discussed in a few articles. Finally, because of it’s manner of inheritance which is autosomal dominant, thus an obstetrics condition affecting 50% of the kids.
As a result, couples expecting to conceive should discuss genetic risks with a clinician during a preconception consultation or should be referred to a high-risk obstetrician during the early stages of pregnancy. For the past three decades, prenatal diagnosis has been possible.
Maternal and neonatal infections exist from factors arising from the superimposition of infections, especially on group B Streptococcus, which leads to neonatal sepsis and sometimes mortality. Any skin disease that would affect the breast can also affect the breastfeeding process. Some of the findings include neuropsychiatric correlations with DD.